SYPHILIS is a playable word

syphilis Scrabble® Dictionary

noun
pl. syphilises
a venereal disease
52 Playable Words can be made from "SYPHILIS"
   2-Letter Words (6 found)
   3-Letter Words (15 found)
   4-Letter Words (17 found)
   5-Letter Words (11 found)
   6-Letter Words (2 found)
   8-Letter Words (1 found)